Skin Stem Cell Imaging and Manipulation/SCIM (Dermatology)

Overview of Services

The epiCURE Stem Cell Imaging and Manipulation Core (SCIM) was established to facilitate skin disease
research via the propagation and manipulation of various state of the art in vitro and in vivo experimental
systems that model skin biology. The overall goal of the SCIM is to assist epiCURE investigators in the
phenotypic and mechanistic analyses of skin disease. To accomplish this goal, the SCIM will provide a wide
array of histological, immunohistochemical, and molecular-based tools to characterize gross and
microscopic morphology, functional features and gene expression in skin of human and genetically
engineered laboratory animals. In addition, the SCIM will provide state-of-the-art techniques for i) isolation,
propagation and functional assessment of skin stem cell lineages, ii) induced pluripotent stem cell systems,
iii) in utero gene targeting, iv) tissue culture systems to analyze genes related to skin diseases by efficient
and systematic overexpression or suppression including CRISPR/Cas9-mediated deletion and v) three-
dimensional imaging platforms specialized for skin. The SCIM is committed to offering assistance to
epiCURE investigators (experimental design/individual protocol development, interpretation of obtained
results, teaching) and assuring effective communication among investigators in order to reduce the
research costs, increase efficiency and further enrich the scientific quality of epiCURE. The SCIM was
specifically designed as resource to support a translational-based pipeline to facilitate skin disease studies
that is able to bridge basic science with translational models. As such, SCIM services will be tailored to the
needs of each investigator in a manner that is highly responsive to the Precision Medicine directive and the
NIAMS mission.

This core is funded by the Department of Dermatology's Skin Disease Resource-Based Center (epiCURE).

NIH/NIAMS project number: 1P30AR069632-01. 

epiCURE logo


David M. Owens, Ph.D - SCIM Core Director

 Ellen Ezratty, Ph.D. - SCIM Core Co-Director

 Liang Liu, Ph.D. - SCIM Core Co-Investigator


Location and hours of operation

Hours Location

Monday through Friday            

9:00 AM - 5:00 PM

Russ Berrie Medical Sciences Pavilion

Room 3-312

1150 St. Nicholas Ave.

New York NY, 10032

Links and Resources  


Name Role Phone Email Location
Rong Du, Ph.D.
Associate Research Scientist - Tissue Culture Services
Russ Berrie Rm 3-312
Angela Warren
Research Administrator
New York