Biomarkers Core Laboratory (Irving Institute/CTSA)

Overview of Services

The Biomarkers Core Laboratory at the Irving Institute for Clinical and Translational Research is an advanced analytical resource center, offering research support to pre-clinical, translational, and clinical investigators at Columbia University Irving Medical Center and other academic institutions.

Our Mission is to offer expertise, state-of-the-art technologies, and instrumentation for the quantitative assessment of biomarkers, drugs, targeted metabolomics, and lipidomics.

Our Services


Biomarker Assays

A Biomarker is defined as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.” We offer immunoassay based manual and automated analytical assays (ELISA/RIA/CLIA/Luminex) for the targeted and multiplexed quantitation of biomarkers in complex biological matrices.


Targeted Metabolomics

Targeted metabolomics is the hypothesis-driven, relative or absolute quantitative assessment of a subset of metabolites often linked to a specific pathway (glycolysis, TCA cycle). We offer several Liquid and Gas Chromatography-Mass Spectrometry (LC-MS/MS, GC-MS/MS) based targeted metabolomics panels including acylcarnitines, amino acids, bile acids, free fatty acids, steroids, organic acids, and Biocrates p180 metabolomics kit.


Targeted Lipidomics

Targeted profiling of a wide range of lipid species from different classes would offer systems-level information on the metabolic status and aid in the novel biomarker discovery. We offer a targeted lipidomics panel comprising 590 individual lipid species belonging to 34 lipid classes including glycerolipids, sphingolipids, and glycerophospholipids.


Pharmacokinetic Profiling

The Biomarkers Core also offers several LC-MS/MS based assays for small molecule drug monitoring for pharmacokinetic profiling. The Core will also develop extensively validated quantitative assays for novel drugs to support PK/PD studies.


Biorepository

The Biomarkers Core provides biobanking support for investigators at Columbia University Medical Center. Our services include biospecimen processing (blood, urine, saliva), aliquoting and -80C freezer storage for the duration of clinical studies.


Consultation

The facility director and the dedicated staff members have extensive expertise in the immunoassay and mass spectrometry-based biomarker assays and targeted metabolomics. Please contact us prior to the initiation of biospecimen collection and/or submission of a service request to discuss blood processing guidelines, core policies and to identify an appropriate analytical strategy (methods and analytical platforms).


Instrumentation:

Roche Cobas Integra ®400 Plus, Siemens IMMULITE® 1000 system, Luminex 200
LC-MS/MS: Waters Xevo TQ, Waters Xevo TQ-S, Agilent 6490, Agilent 6410 and AbSciex API4000 Triple Quadrupole (QQQ) Mass Spectrometers integrated either with nanoLC or UPLC systems
GC-MS/MS: Agilent 6890 Single Quad and Agilent 7890A Triple Quad Mass spectrometers

Leadership


Renu Nandakumar, PhD

Director
212-305-0871
rn2374@cumc.columbia.edu
For information on existing services or for the development of new assays 

Location and hours of operation

Hours Location

 Monday - Friday  

 

9 AM - 5 PM

PH10-105


622 W 168th Street

 

New York, NY 10032

 

Links and Resources

Biomarker Core Laboratory Website

Contacts

Name Role Phone Email Location
Renu Nandakumar, PhD
Director
 
212-305-0871
 
rn2374@cumc.columbia.edu
 
PH10-105A
 

Service list


Search available services: View: by category alphabetically
ELISA/RIA (1)
LCMS (1)