Genome Engineering Core Facility (Systems Biology)

Welcome to GECO

At the Genome Engineering CoLab (GECO), our aim is to develop genome engineering tools that unravel the complex genetic underpinnings of diseases. We use these tools in collaboration with researchers working to understand and treat a broad range of human diseases, driving medical discovery and the translation of genetic insights into therapeutic solutions. 

GECO helps collaborators in experimental design and execution by helping them choose the best model system, perturbation type, challenge, and readout for their goals. Our tools include CRISPR knockout, interference, base editing, CRISPRoff, and ORF overexpression. Typical readouts include amplicon sequencing and scRNA-seq.        

Overview of Services

GECO provides two categories of services:

     1) genome engineering, e.g., CRISPR screens with amplicon-seq or scRNA-seq readout, including CRISPR/i/a/off, base editing, and Perturb-seq/CROP-seq, and

     2) spatial profiling with our 10X Genomics Xenium. 

See our website for more details, or contact us at genome@columbia.edu. 

For more information about our 10x Xenium services and pricing, please visit Spatial Profiling with the 10X Genomics Xenium.

Team

Jeremy Worley, PhD; Assistant Professor at CUIMC, Department of Systems Biology; Director, Genome Engineering Core (GECO)

Mikko Turunen, PhD; Assistant Professor at CUIMC, Department of Systems Biology

Bryan Diaz, MS; Spatial Profiling

Justyn Chang, BS; Functional Genomics

Peter Sims, PhD; Academic Director of Columbia University Sulzberger Genome Center

Location and hours of operation

Links and Resources

1. [ link or resource # 1. To add a hyperlink, select text and click ]
2. [ link or resource # 2 ]
3. [ etc... ]

Contacts